Despite these risks, immune checkpoint inhibitors represent one of the most promising advances in cancer treatment in the past 50 years. These toxicities might affect almost every organ in the body and occur at any point during treatment. These occur when the stimulation of their immune system results in an immune attack on their normal tissues. While most patients tolerate treatment quite well, some develop autoimmune side effects. These agents are administered intravenously, usually every 2-6 weeks depending on the specific medication. ![]() Checkpoints prevent people from developing autoimmune diseases such as lupus, Crohn’s disease, and other conditions in which the body attacks healthy tissue and organs.Ĭheckpoint inhibitor drugs such as Keytruda essentially take the brakes off in a controlled way to enhance the patient’s immune system response to cancer. If you imagine your immune system as a vehicle, checkpoints would be the brakes. Two types of cancer immunotherapy Checkpoint inhibitors Recent developments have focused on immune checkpoint inhibitors and on CAR-T cell therapy. To provide that, we must carefully select patients who will benefit most and determine the most appropriate available treatment. However, it can give certain patients more precious time with family and friends. Today’s immunotherapy is not a cure for late-stage lung cancer. In fact, the findings suggest that earlier introduction of immunotherapy for certain patients might one day become the standard treatment.īut while the data are promising, we must not be too eager to declare victory. The results are encouraging: Patients who received the dual therapy lived longer than those who received only chemotherapy. In the study, the immunotherapy drug pembrolizumab (Keytruda®) was combined with chemotherapy to determine whether the dual approach was more effective than chemotherapy alone for metastatic nonsquamous non-small cell lung cancer. Most recently, lung cancer has received attention for data released from a study published in The New England Journal of Medicine and featured in The New York Times. Promising data have emerged to indicate its effectiveness against many cancers, including lung, kidney, melanoma, and some colon cancers. ![]() These treatments stimulate the patient’s own immune system to attack a disease, much like it would a virus or another foreign invader. For nearly five decades, doctors have used various forms of immunotherapy to treat certain cancers.
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